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KMID : 0369820150450070625
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Jorunal of Korean Pharmaceutical Sciences
2015 Volume.45 No. 7 p.625 ~ p.631
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Comparison of solid lipid nanoparticles for encapsulating paclitaxel or docetaxel
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Baek Jong-Suep
Cho Cheong-Weon
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Abstract
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The aim of this study was to compare physicochemical properties of solid lipid nanoparticles (SLNs) on drug nature. These SLNs were fabricated for formulating paclitaxel (PTX) or docetaxel (DTX). To make small, and highly encapsulated SLNs, the SLNs consisted of compritol 888 ATO (glyceryl behenate) as lipid matrix, poloxamer 188 or solutol HS 15 as surfactant and soya lecithin as co-surfactant. The SLNs were characterized by particle size, zeta potential, in vitro release study and cytotoxicity study. In this study, SLNs showed different physicochemical properties and release profiles according to used solid lipid. In case of particle size, PS1 and DS1 showed bigger particle size than those of PS2 and DS2. Encapsulation efficiency (%) of DTX-loaded SLNs exhibited higher than that of PTX-loaded SLNs. And, DTX-loaded SLNs showed prolonged release up to 24 h. We found that SLN using solutol HS 15 as surfactant exhibited enhanced cellular uptake on MCF-7/ADR cells. These results suggest that different drugs and surfactant effect on physicochemical properties regardless same composition.
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KEYWORD
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Solid lipid nanoparticle, Docetaxel, Paclitaxel, In vitro release, Compritol 888 ATO
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